Christina Applegate has revealed the shocking amount of times that she has been rushed to the hospital for an illness related to her multiple sclerosis (MS).

The 53-year-old actress - who recently revealed an early symptom of MS that she missed - got candid about her battle with the chronic, autoimmune disease that affects the central nervous system on her MeSsy Podcast.

She answered a fan question about her battle as she said: 'For three years, since I was diagnosed, I’ve been in the hospital upwards of 30 times from throwing up and diarrhea and pain.

'That is unimaginable, OK? They’ve done every test known to man on me, put so much radiation into my body from CT scans to everything else.'

Christina did reveal some positive news, however, as she said that she believes that she had figured out what the issue is within the last month.

As the fan asked about the vomiting and diarrhea from their battle with MS, the Married With Children actress replied: 'Now, maybe this isn’t what’s happening, but I’m just going to tell you this. Talk to your doctor about motility issues, okay.

'Because one of the things with MS is that it slows down our organs, you know, not like completely, but there is a slowing of the function of your organs.

'I have noticed that — and I’m going to be really honest — if I have to poop, I puke.'

 Christina also said that she was going to get a colonoscopy and said she brought the fan's email to show the doctor.

She said: 'My neuro doesn’t — God bless her — says that’s not an MS thing.

'So, I’m sorry, there’s got to be a correlation here, and I’m not a doctor. I’m not giving medical advice. I’m just saying, just think about that, OK? Because I’m in the middle of the same exact situation, and it f***ing sucks, and it’s scary.' 

Christina joked that her 'favorite part' of her MS battle is having diarrhea and vomiting simultaneously. 

She said: '“Always have a little trash can next to your toilet. Because you can do both without it being messy.

'I had one yesterday.'

Christina launched the MeSsy podcast in March 2024 as she co-hosts it with fellow actress Jamie-Lynn Sigler who is also battling MS.

Back in December, Christina revealed on the podcast she missed an early symptom of multiple sclerosis (MS)  when she fell on the set of her Netflix series Dead to Me.

'I remember falling that day,' Applegate told co-host Jamie-Lynn, 43 and guest Liz Feldman, 47, the creator of Dead to Me.

The Hollywood, California native said she fell while filming a running sequence in a field on the latest edition of the podcast, titled Putting Life on Paper. 

Applegate said of her fall: 'Hi, first sign of MS! So, not to bring everybody down, but there it was.'

The Emmy-winning actress - who publicly announced she has been battling MS in August of 2021 - and The Sopranos alum Sigler, who publicly revealed her MS battle in January of 2016, have spoken about their respective health battles on the podcast.

Feldman noted that she had observed Applegate, who starred on the series during its three-season run from 2019-2022, experiencing physical symptoms, but chalked it up to long hours on set.

'I remember you losing your balance when we were shooting the pilot a couple of times,' Feldman said. 'It was very hard to figure it out because, you know, I remember one time, it was really late at night. 

'We'd been shooting probably 14 or 15 hours … it seemed completely reasonable that anybody would be collapsing.'

Applegate - who continued work on the third season of the show after she was diagnosed - said that 'it was MS.'

Feldman said she was empathetic in watching Applegate - also known for Married... with Children and Don't Tell Mom the Babysitter's Dead - soldier on in production amid her health crisis.

'I could just sense A, that she was scared, and B, that something was wrong … that something in her body was not working the way that she wanted it to,' Feldman said. 'There's no handbook for this. 

'I can't compare it to any experience I've ever gone through with a person before.'

Feldman said she 'just always tried to put [Applegate's] health first in my mind' as cameras rolled on the third season of the show, telling the actress at times that her well-being was priority over 'just a TV show.'

Feldman said she told Applegate, 'At the end of the day, yeah, maybe it'll reach people and help people and entertain people, but this is your life.'

Applegate said that Feldman and the Netflix show's crew went out of their way to accommodate her amid her MS battle, stopping filming for a week to let her recuperate. 

'That would not happen anywhere else, so my gratitude towards you guys being humans - because you should be humans and love other humans - is astounding,' Applegate said. 'I can't even tell you … that's not the normal reaction.'

The series also starred Linda Cardellini, James Marsden, Sam McCarthy, Luke Roessler, Max Jenkins, Diana Maria Riva and Brandon Scott.

Applegate and Cardellini played the respective roles of Jen Harding and Judy Hale on the dark comedy, as a pair of women in grief who grow closer amid therapy.

The show was nominated six times for Primetime Emmys, with Applegate receiving two nods for her work in the lead role.

Applegate told Kelly Clarkson in a December 2022 interview that the show provided her with 'this weird platform of dealing' with the life-changing diagnosis.

'The beauty of Dead to Me is that ... I didn't have to be on all the time and I didn't have to make all the jokes and I could fall apart in a scene,' Applegate said. 'And it was, like, me. It was my soul actually falling apart, unfortunately, in front of the world, but it was cathartic in a beautiful way.'