Its origins remain a mystery with the earliest references in Scotland dating to the late 15th century.

But the next, somewhat futuristic step in the art of whisky making will enter the history books – with the water of life to be distilled in space for the first time.

Scientists are embarking on the experiment in a bid to measure how the spirit ages in the harsh environment beyond the Earth’s atmosphere.

Engineers in Scotland and Japan are planning to put Scotch on a rocket in 2028, sending a satellite containing samples of whisky and its base ingredients on a five-year mission to orbit the Earth.

It is hoped the frequent changes between extreme heat and freezing cold experienced by the drink as it rotates the planet every 90 minutes could speed up the maturation process.

This could potentially open the door to future production of space-aged whisky, with expectations of ‘very bold’ flavours from the unusual journey.

While such a dram would command astronomical prices due to the cost of launching and recovering the liquid, collectors are already known to pay hundreds of thousands for some of the rarest bottles.

Dr Gilles Bailet, of the University of Glasgow, said a number of students have travelled from Scotland to Japan to help to co-design the ‘cubesat’ which will contain the tiny whisky samples and ingredients.

The research is also expected to provide insight into how orbital factories could work, which could develop molecules for medications difficult to produce on Earth.

He said: ‘We want to see what the effect of a space environment is on the aging of the whisky.’

Dr Bailet added: ‘We’ve got the best people here in Scotland to be able to inform that, with centuries of experience, so we can bring this whisky experience into space.’

The current plan for the whisky experiment – nicknamed ‘Space Puffin’ – is to launch the cubesat in 2028 on a SpaceX supply mission to the International Space Station, before deploying it into orbit from the Japanese module of the space station.

The science around the process of whisky ‘breathing’ as it ages in wooden casks is not well understood, Dr Bailet said, but the cycles could happen much faster in space – where temperatures can quickly vary between minus 150 degrees to 200 degrees.

Dr Bailet continued: ‘We build our spacecraft to be able to get an environment which is better for the whisky, but this wood will breathe faster than on Earth.

‘And so we are hoping that we’ll be able to accelerate the ageing to be able to get something more interesting.’

The whisky on the cubesat will be monitored while it is in space, feeding data on its colour and chemical composition back to the team on the ground.

Among the things the scientists are keen to demonstrate, is how ethanol, which plays a role in the production of many drugs, can be extracted in orbit.

While the cubesat will not be recovered at the end of its five-year mission, Dr Bailet said he is keen to scale up whisky maturation in space and develop a system for launching Scotch into space and landing it on Earth after a spell outside the atmosphere.

He said: ‘We are really keen to be able to actually fly a full whisky-making system, with a full cask, if we’re able to collaborate with investors or other people interested about it.

‘But it’s totally in the realm of possible to bring back something like a litre of whisky within the next three to five years.’

He hopes this process would produce ‘really bold whiskies’ with ‘extremely complex flavour profiles’.

While whisky has previously been into space as part of an experiment to understand flavour, it did not leave the temperature-controlled confines of the International Space Station.

Different distilleries in Scotland and Japan are expected to contribute the drink, though these have not been chosen yet.

The initial visit to Japan is the result of a grant from distillery-design consultancy Allen Associates.

Geoff Nisbet, lead process design engineer at the consultancy, said: ‘We often say that our fingerprints are found all over Scotland’s distilleries — we never expected the next set might end up in space.

‘We’re delighted to support a project which brings together Scotland’s world-renowned whisky industry, engineering innovation and the next generation of engineers.

‘There is also something quite fitting about Scotland and Japan being brought together through whisky once again, this time with a project looking far beyond the distillery itself.’