Предприятие. A2 RESEARCH, JV. [Редактировать]

Экономические характеристики

#ХарактеристикаДата измеренияЗначение
1Численность персонала (по DUNS number) (832501642), чел.2013-01-011
2Численность персонала (по DUNS number) (832501642), чел.2014-07-031
3Годовой доход (по DUNS number) (832501642), млн. долл.2013-01-010.1
4Годовой доход (по DUNS number) (832501642), млн. долл.2014-07-030.1

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..., Inc. (Ames Research Center) Logical Innovations, Inc. (Armstrong Flight Research Center) ZIN Technologies, Inc. (Glenn Research Center) Fibertek, Inc..., JV (Langley Research Center) AMRO Fabricating Corporation (Marshall Space Flight Center) A2Research, JV... exploration, scientific discovery, and aeronautics research. M I S S IO N STATEM EN T ✦✦ To advise... 1 NASA DUSTRY ORUM R E P R E S E N T AT I V E C O M P A N I E S AMES RESEARCH CENTER GODDARD SPACE FLIGHT CENTER... Business Small Business (ARTS) ASRC Research and Technology Solutions Edge Space... ARMSTRONG FLIGHT RESEARCH CENTER InuTeq, LLC Small Business GLENN RESEARCH CENTER Science Applications International Corporation (SAIC) Large Business Universities Space Research... Technology, Inc. Large Business Linc Research Small Business Northrop Grumman Large... Innovations, Inc. Small Business LANGLEY RESEARCH CENTER Genex Systems, LLC Small... Large Business A2 Research, JV Small Business 3 AE3 PARTNERS, INC. NASA AMES RESEARCH CENTER... (IDIQ) tasks at NASA Ames Research Center. In addition, AE3 has... IDIQ tasks at NASA Ames Research Center (ARC). These tasks are... INNOVATIONS, INC. NASA ARMSTRONG FLIGHT RESEARCH CENTER Tell us about your... Research Center (AFRC), Ames Research Center (ARC), Johnson Space Center (JSC), Glenn Research... customers. After years of marketing, research, and growth (that began with... 7 ZIN TECHNOLOGIES, INC. NASA GLENN RESEARCH CENTER Tell us about your...-registered. ZIN has supported unique research and development programs in the... a wide range of new scientific research with direct application to products.... ZIN started operating is first research and production facility for the... percent of the physical science research on ISS has been developed... as the Small Business Innovation Research (SBIR) program, to develop the... at four NASA Centers (Ames Research Center, Goddard Space Flight Center..., LLC; dba MIDLAND GSS, JV NASA LANGLEY RESEARCH CENTER Tell us about... provided by the Midland GSS JV staff, combine to offer NASA... based at the NASA Langley Research Center (LaRC) in Hampton, VA... the NASA Center(s): Midland GSS JV and our subcontractor Genex Systems... measurement services for science and research projects, GSS measurement, GSS mapping... analytics, Software Application Development, and research and development of next-generation... Solutions, LLC; dba Midland GSS, JV 501 North Market Street Maryville... of budget challenges. 21 A2RESEARCH, JV NASA STENNIS SPACE CENTER AND... capabilities: Calibration in process A2Research, JV (A2R) is the contractor for... (MAF). A2R is a joint venture (JV) with Alcyon as the majority... at SSC and MAF. A2Research, JV 4801 University Square, Suite 31... INFORMATION NASA Headquarters (HQ) Glenn Research Center (GRC) Glenn A. Delgado Eunice....office@jpl.nasa.gov Ames Research Center (ARC) Jet Propulsion Laboratory...@jpl.nasa.gov Armstrong Flight Research Center (AFRC) Jet Propulsion Laboratory...-smallbusiness@mail.nasa.gov Langley Research Center (LaRC) NASA Office of...



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....nypost.com/p/news/business/netflix_wishing_on_starz_deal_eQnj155VqsKPJWf4dwJMwM. 4 A2(4)-2 exploit in this way the... 1 seemed broadly consistent with other research reviewed below (see paragraphs 41... 7% 0% 50% 100% Source: CC’s consumer research (December 2010). Note: Responses were... Movies. 39 Consumer research 41. We reviewed consumer research by Sky and... research are summarized in Table 4. 23 The results of earlier Sky research... also summarize some other Sky research. This research was conducted in 2011... Table 1, []. 47 [] [] Source: []. 3. [] 4. [] 48 Sky research on attitudes towards Internet-distributed... [] [] 48 [] 47 4(2)-30 TABLE 2 Sky research on customer attitudes towards Internet... Sky Movies subscription. TABLE 3 Sky research on customer attitudes towards Internet... Sky research 10. In November 2011, Sky conducted some qualitative research 49... Contents 1 Executive Summary ............................................................................... 1 2 Background and Research Objectives ................................................... 5 3 Research Design .................................................................................... 6 4 Survey Findings ..................................................................................... 7 4.1 Pay... these surveys. Ofcom research 2. Ofcom’s pay-TV research during 2007 asked customers... (tested across two phases of research) were: (1) Sky Sports A showing a variety...). Sky research 7. Sky provided us with data from two consumer research exercises... (Sky Movies pricing and packaging research). (b) The second was commissioned by... and packaging research suggested, among other things, that []. 9. This research also indicated that []. 10. This research also yielded some... of price ‘elasticities’ reported in research undertaken for business purposes. In... Capital is a strategy/research/development consultancy. The market research was carried out....0 N/A 13.4 50.9 20.7 8.7 N/A 19.7 Source: Research bias and the hypothetical monopolist... cancelling their subscriptions. Ofcom research 2. In Ofcom’s 2007 research, Sky Movies subscribers... for different channel packages. This research found that: (a) Sky Movies subscribers... considered). Both qualitative and quantitative research was conducted. [] 4 7. Sky also carried... Contents 1 Executive Summary ...................................................................................... 1 2 Background and Research Objectives .......................................................... 5 3 Research Design ........................................................................................... 6 4 Survey Findings ............................................................................................ 8 4.1 Respondent... commissioned GfK NOP to undertake a research exercise to help better understand... 5 GfK NOP 3 22. Research Design A two-stage research approach was adopted. First... exclude all Sky’s joint venture (JV) activities and ‘available for sale...’s consumer research 1. We begin by providing a summary of the consumer research conducted... of this research in more detail. 2. Ofcom carried out consumer research to... constructed based on consumer research: Ofcom FAPL Omnibus research in March 2005... it. Pay-TV retailers research Sky consumer research 28. Sky provided us... research 36. [] However, it provided us with various presentations and market research... consumer research 42. BT provided us with various pieces of market research... inquiry than to research by independent organizations or to research carried out... provisional findings, BT said its research had not been commissioned specifically... research was conceived and undertaken by an independent and reputable market research... of its research referred to bespoke pieces of consumer research commissioned in... BT’s research was undertaken by an independent and reputable market research agency... in merger inquiries, sound statistical research required that the specific hypotheses... for a different research purpose testing a different hypotheses) than research undertaken with the... without publishing the details of research and research methodologies used by other...’ research which we did not publish, it was on commercially confidential research... this research. However, we did publish the key results from this research... less weight to BT’s research than to the research we commissioned, we... that research should never be carried out online, just that online research...-to-face or telephone research. We regarded online research as appropriate to...). 47. BT’s first piece of research also investigated preferences for a subscription... inquiry than to research by independent organizations or to research carried out... that research should never be carried out online, just that online research... research may be less reliable than face-to-face and telephone research... that respondents to the consumer research overstated unsubscribing/switching in relation... rate downstream. BARB Broadcasters’ Audience Research Board Ltd. The pan-industry...



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... of Industrial Engineering and Operations Research. We thank our respective universities...: Input: A sequence of n numbers ha1 ; a2 ; : : : ; an i. Output: A permutation (reordering) ha10... 1: Input: A sequence of n numbers ha1 ; a2 ; : : : ; an i. Output: A permutation (reordering) ha10...: Input: A sequence of n numbers A D ha1 ; a2 ; : : : ; an i and a value . Output: An... a polynomial P .x/ D n X ak x k kD0 D a0 C x.a1 C x.a2 C C x.an 1 C xan / // ; given the coef... master theorem 99 f .n/ f .n/ a f .n=b/ … f .n=b/ a f .n=b/ a af .n=b/ a logb n a … a … a … a … a … a … ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ f .n=b 2 / f .n=b 2 /…f .n=b 2 / a … … a … a2 f .n=b 2 / a … … f .n=b 2 / f .n=b 2 /…f .n=b 2 / f .n=b 2 / f .n=b 2 /…f .n=b 2 / ‚.nlogb a / ‚.1/ ‚.1/ ‚.1/ nlogb a X logb n 1 Total: ‚.nlogb... / … f .n2 / a … f .n2 / a … a … f .n2 / … f .n2 / a … a … ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ f .n2 / a … … a2 f .n2 / f .n2 / … f .n2 / a … a … … f .n2 / ‚.nlogb...: Input: A sequence of n numbers ha1 ; a2 ; : : : ; an i. Output: A permutation (reordering) ha10... sorted ordering is a3 D 5 Ä a1 D 6 Ä a2 D 8. There are 3Š D 6 possible permutations of... for any nonnegative integer a: ! a : (11.6) a2 D a C 2 2 We have "m 1 # X nj2 E j D0 !!# nj... 371 .A1 .A2 .A3 A4 /// ; .A1 ..A2 A3 /A4 // ; ..A1 A2 /.A3 A4 // ; ..A1 .A2 A3 //A4 / ; ...A1 A2 /A3 /A4... a0 RECURSIVE -ACTIVITY-SELECTOR(s, f, 0, 11) m=1 a2 RECURSIVE -ACTIVITY-SELECTOR(s, f, 1, 11) a1... since X w 0 .e/ w 0 .A/ D with jV j e2A X .w0 D w.e// e2A D .jV j 1/w0 X w.e/ e2A D .jV j 1/w0 w.A/ for any..., we have A0 .1/ D 1 C 1 D 2, A1 .1/ D 2 1 C 1 D 3, and A2 .1/ D 21C1 .1 C 1/ 1 D 7. 574 Chapter 21 Data... Disjoint Sets We also have A.2/ 2 .1/ A2 .A2 .1// A2 .7/ 28 8 1 211 1 2047 A3 .1/ D D D D D D and... representation of a graph G consists of a jV j jV j matrix A D .aij / such that ( 1 if... operations take O.E ˛.V // time. Moreover, since ˛.jV j/ D O.lg V / D O.lg E/, the total running... at most jV j 1 edges, and so k Ä jV j 1. Each of the jV j 1 iterations of... that there exists a sequence of jV j 1 relaxation steps that produces :d D ı.s; / for... sort h 1 ; acyclic with topological sort h jV j ; jV j 1 ; : : : ; 1 i. 2; :::; jV j i and that Gb is Suppose... each vertex in the order jV j ; jV j 1 ; : : : ; 1 , relaxing edges of Eb that... wi .u; / D 2wi 1 .u; / C 1. Then, prove that 2ıi 1 .s; / Ä ıi .s; / Ä 2ıi 1 .s; / C jV j for all 1 .u; / or 1 2 V. d. Define... a general directed graph G D .V; E/ is then f .jV j ; jEj/ C O.V C E /. 25.3 Johnson’s algorithm for.... The algorithm returns the usual jV j jV j matrix D D dij , where dij D ı.i; j /, or... lg V = lg V /5=4 /. Another line of research demonstrates that we can apply... improve upon running Dijkstra’s algorithm jV j times when jE j D o.E/. Baswana, Hariharan... can become critical at most .jV j 2/=2 D jV j =2 1 times more, for a total of... E, directed from L to R, along with jV j new directed edges: E 0 D f.s; u/ W u 2 Lg [ f.u; / W .u; / 2 Eg... G. A function h W V ! N is a height function3 if h.s/ D jV j, h.t/ D 0, and h.u/ Ä h. / C 1 for every residual edge... initial height function h, given by ( jV j if u D s ; u:h D (26.16) 0 otherwise : Equation..., p is a simple path, and so k < jV j. For i D 0; 1; : : : ; k 1, edge . i ; i C1 / 2 Ef . Because...-relabel algorithms 743 we have h.s/ Ä k < jV j, which contradicts the requirement that... s in Gf . Let p D h 0 ; 1 ; : : : ; k i, where 0 D u, k D s, and k Ä jV j 1 because p is simple. For i D 0; 1; : : : ; k 1, we... these inequalities over path p yields u:h D 0 :h Ä k :h C k Ä s:h C .jV j 1/ D 2 jV j 1. Corollary 26.21 (Bound on... at most 2 jV j 1 per vertex and at most .2 jV j 1/.jV j 2/ < 2 jV j2 overall. Proof Only the jV j 2 vertices in... operations performed is at most .2 jV j 1/.jV j 2/ < 2 jV j2 . Lemma 26.20 also... nonsaturating pushes is less than 4 jV j2 .jV j C jEj/. P Proof Define... to be less than .2 jV j/.2 jV j2 / C .2 jV j/.2 jV j jEj/ D 4 jV j2 .jV j C jEj/. Since ˆ 0, the... nonsaturating pushes, is less than 4 jV j2 .jV j C jEj/. Having bounded the... the properties that u:h < jV j implies u:h Ä ıf .u; t/ and that u:h jV j implies u:h jV j Ä ıf .u; s/. 26.4-9 ? As in... the property that u:h < jV j implies u:h D ıf .u; t/ and that u:h jV j implies u:h jV j D ıf .u; s/. The total time... I NITIALIZE -P REFLOW has been run, s:h D jV j and :h D 0 for all 2 V 2 (because V contains... for which :h > k, to set :h D max. :h; jV j C 1/. Show that the resulting attribute... contains a source vertex s, vertices A1 ; A2 ; : : : ; An , vertices J1 ; J2 ; : : : ; Jm.... According to your campaign staff’s research, you can estimate how many... applications. Any textbook on operations research is filled with examples of... of vertices, and it has 2 jV j2 C jV j 2 constraints. It is usually... remains an active area of research. V. Klee and G. J. Minty constructed an... this empirical observation. A line of research begun by K. H. Borgwardt, and carried...



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... de analitos 4.a1. Materiais. 184 4.a2. Preparação das soluções dos...] Wolff SP, Barcal ZA, Hunt JV, em The Maillard reaction in...] Wolff SP, Jiang ZY, Hunt JV. Free Radical Biol. Med. 1991; 10: 339. [154] Hunt JV, Bottoms MA, Mitchinson MJ. Biochem...: 985. [19] Thomson BA, Iribarne JV. J. Chem. Phys. 1976; 64: 2287. [20] Iribarne JV, Thomson BA. J. Chem. Phys. 1979... aminoácido e amina, acima referidos. 4.a2. Preparação das soluções dos... (10 -5 M) (pH 7.5), behave differently (Fig. 2 – A2, B2, C2 and D2). In... up to 10 -4 – 10 -5 M (Fig. 2 – A2, B2, C2 and D2). Above... spectra seems to occur (Fig. 2 – A2, B2, C2 and D2). With... concentration above this value (Fig. 2 – A2, B2, C2 and D2). Fig. 2 – A2, B2, C2 and D2, which ... ion abundances variation in Fig. 2 – A2, B2, C2 and D2. In Fig. 2 – A2, B2, C2 and D2, it... the low-concentration range (Fig. 2 – A2, B2, C2 and D2), ESI... abundances remain almost constant (Fig. 2 – A2, B2, C2 and D2). Thus... analyte concentrations in solution (Fig. 2 – A2, B2 and C2), in comparison... concentration in solution, i.e. 10 -5 M (Fig. 2 – A2, B2, C2 and D2) and...-03 1,0E-02 [Acetyl-lysine] / M (A2) 1 1 m/z 261 ions m/z 261 ions 0,1 Ion..., respectively. 1 and 2 (e.g. in A1 and A2) refer to analyte solutions (pH.... 2001; 20: 362. 21. Iribarne JV, Thomson BA. J. Chem. Phys. 1976...: 2287. 22. Thomson BA, Iribarne JV. J. Chem. Phys. 1979; 71: 4451... protein glycation and cross-linking research owing to its high sensitivity.... Hydrogen ion buffers for biological research. Biochemistry 1966; 5: 467. 40. Good... m/z 295 217 100 217 100 (A2) Relative Abundance (%) Relative Abundance (%) Cap... (B) 2,3-hexanedione. A1 and B1: 5 min; A2 and B2: 1 day. The m/z values... 80 261 100 80 100 (A2) Relative Abundance (%) Relative Abundance (%) 300.... A1, B1 and C1: 5 min; A2, B2 and C2: 1 day; A3.... Skamarauskas JT, McKay AG, Hunt JV. Free Rad. Biol. & Med. 1996... 40 * 329 20 477 0 50 (A2) 150 250 350 450 550...-1,2-propanodiona (A) e 2,3-hexanodiona (B). A1 e B1: 5 min; A2 e B2: 1 dia. Os iões assinalados...



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... of Physics and Technology, National Research Tomsk Polytechnic University, Tomsk, Russia... for updates Physics Department, National Research Tomsk State University, Tomsk, Russia... article may be used for research, teaching, and private study purposes.../10.1080/00268976.2014.912360 RESEARCH ARTICLE On the ‘expanded local..., National Research Tomsk Polytechnic University, Tomsk, Russia; b Physics Department, National Research Tomsk... E 1 s s = s γ σ s = (−1)γ + = + s γ σ s γ σ s s s s γ σ A1 = A1 A1 E 1 A1 = =− . (11) E 2 E 2 E 2 A2 = 1, A2 E 2 = A2 E 2 E 1 =− E 1 E 1 A2 E 1 1 =√ , 2 1 E = . 1 2 (12) E 2 (13) (14) This allows... γ (for the C3v group, [A1 ] = [A2 ] = 1, and [E] = 2). The values σγ s s are the...-dimensional irreducible representations A1 and A2 ); (−1)A1 = ( − 1)E = − (−1)A2 = 1; the symbol ⊗ denotes the..., or belong to the A1 /A2 irreducible representations, the relations being..., in particular, for the a1 /a2 splittings of K = 3 (K = |k|) levels. The parameters... can take the values A1 ,A2 , or E. In this case, different... diagonal blocks of A1 or A2 symmetry in the following form... , vE , J+4 − J−4 + + (35) 1 v 1 v 2 1 v 2 α + αJ J + αK Jz + αJv J J 4 + αJv K J 2 Jz2 2 2 2 v + αKK Jz4 + · · · + αJv J K J 4 Jz2 + · · · + αJv KK J 2 Jz4 + · · · , 2536.... B vE = β v Jz + βJv Jz J 2 + βKv Jz3 + βJv J J 4 Jz C vE J+2 − J−2 + βJv K J 2 Jz3 + · · · , 1 1 1 = γ v + γJv J 2 + γKv Jz2 + γJvJ J 4 2 2 2 + γJvK J 2 Jz2 + · · · + γJvJ K J 4 Jz2 + · · · , + iF + δJv K J 2 Jz3 + · · · , 1 1 1 = κ v + κJv Jz2 + κKv Jz2 + κJv J J 4 2 2 2 + κJv K J 2 Jz2 + · · · , Downloaded by... k = k − k = ± 3, they do not split a1 /a2 levels. The operator (2) HvE,vE... with n = 2m provide the a1 /a2 splittings of energy levels with... blocks of the A1 –E, or A2 –E, type Coriolis interaction operators which... vibrational states of the A1 /A2 symmetry, on one hand, and... | [A (J+ + J− )]+ + iB vA1 ,v A2 3 + ηK Jz + ηJvAJ 1 ,v A2 Jz J 4 + ηJvAK1 ,v A2 Jz3 J 2 vA1 ,v A2 5 + ηKK Jz + ηJvAJ 1J,v A2 Jz J 6 + ηJvAJ 1K,v A2 Jz3 J 4 vA1 ,v A2 7 1 ,v A2 + ηJvAKK Jz5... interactions of the A1 –A1 , A2A2 , or E–E type In agreement with... ,v E , J+2 + J−2 + vA1 ,v E + + GvA2 ,v E , J+4 + J−4 + HvA1 ,v A2 = |vA1 v A2 |{ηvA1 ,v A2 Jz + ηJvA1 ,v A2 Jz J 2 HvA1 ,v E = |vA1... –A2 Coriolis type interactions has the following form: GvE = θ v Jz + θJv Jz... ,v e , β vai ,v e , . . . , etc. (i = 1, 2). v 3 D vE = δ v Jz + δJv Jz J 2 + δK Jz + δJv J Jz J 4 F vE + vA2 ,v E k J+6 + J−6 + ··· , where... is responsible for the a1 /a2 splittings in (K = 3) rotational states in vibrational states of A1 or A2 symmetry, being calculated using the... splittings, ηv E , Coriolis interaction parameters, ηv A1 ,v A2 , and Fermi interaction parameters, ηvn... values. 5.5. Parameters of the a1 /a2 (K = 1) rotational splittings, γ v E , Coriolis interaction parameters... γ vE which describe the a1 /a2 (K = 1) rotational splittings in the vibrational... from the analysis of a1 /a2 (K = 1) splittings in the fundamental bands... from Table 2 that the a1 /a2 (K = 1) splitting parameters γ vE are non... η. lλ lμ lν 1 2 3 4 5 6 1 1 1 1 2 0 0 0 0 0 0 1 1 2 2 2 0 0 0 0 0 0 0 0 0 0 0 2541 cλ 1 −1 −1 1 −1 −1 −1 −1 −1 −1 1 cμ a cν lλ lμ lν E E A1 /A2 E E A1 /A2 E A1 /A2 E A1 /A2 E −1 1 1 −1 1 2 1 1 1 2 2 2 1 1 1 1 2 0 30 3 0 3 0 3 0 3 0 3 0 1 1 1 1 1 1 1 1 cλ cμ 1 1 1 −1 −1 −1 1 1 −1 1 a cν A1 /A2 1E 2E 1E.../2E 1E 2E 3E A1 /A2 1 1 1 −1 1 1 −1 1 1 1 that column the type of... parameter of Equation (34); = A1 /A2 corresponds to the ηvA1 ,vA2... 3E A1 E A1 E E E E E E E A1 A2 A1 A2 1E 2E vλ lλ vμ lμ vν lν 11 22 11... A2 E A1 A2 E A1 A2 2E 3E 3E A1 A2 A1 A2 A1 A2 2 4 2 2 4 √ 2√3 2 3 2 2 2 2 and β v dμ(..) ,v . dν(..) 2 −2 2 2 2 −2 2 −2 2 −2 (..) E E E E A1 A2 A1 A2... al. Values of some a1 /a2 splitting parameters, γ vE , of the... mother and substituted molecules: Aba ωa2 αac = αbc ωc2 . (75) a Here... the states of A1 and A2 symmetry; N = 0, 1, . . . , {(J − 1)/3} for the states of... symmetrised in the C3v group: R 1(1,A2 ) = J0 = Jz i 1(1,E) R1 = − √ (J− − J+ ) = Jy 2 1 1(1,E) R2... 1 ([J0 , J− ]+ + [J0 , J+ ]+ ) 2 i = ([J0 , J− ]+ − [J0 , J+ ]+ ) 2 1 = − √ J+2 + J−2 2 i = √ J−+ − J+2 , 2 J 2 J0 R 3(1,A2 ) = − √ 3 i 3(1,E) R1 = √ J 2 (J− − J+ ) 6 1 3(1,E) R2 = − √ J 2 (J− + J+ ) 6 i R 3(3,A1 ) = √ J−3 − J+3 2 1 R 3(3,1A2 ) = − √ J−3 + J+3 2 5 3 3 1 J0... ) = |v 0 ; 1 (v 6p = 0 a1 ) = √ (|v 6p + |v − 6p ), 2 i (v 6p a2 ) = − √ (|v 6p − |v − 6p ); 2 1 (v 6p + 1 e1 ) = √ (|v 6p... + 2) ); 2 1 (v 6p + 3 a1 ) = √ (|v 6p + 3 − |v − (6p + 3) ), 2 i (v 6p + 3 a2 ) = − √ (|v 6p + 3 + |v − (6p + 3) ); 2 1 (v 6p + 4 e1 ) = √ (|v 6p...



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..., AM Eis-Hübinger, S Diedrich 4 16 Research Articles Is the recent emergence... German strains assigned to subclade A2 were identified in adult patients... C-terminus of VP1 of subclade A2 strains. However, there are at... 2014; France 2014 (n=11/16) A2 China 2012; Netherlands 2012-2014... > 0.97) designated A1 (n=5 strains) and A2 (n=11 strains). The French A1... and the Netherlands. The French A2 viruses clustered with viruses recovered... J670/71 B1 B2 C A1 A2 0,1 The phylogenetic analysis is based... of all three current subclades (A2, B1, B2) were selected for... strains, seven belonged to clade A2 and 30 belonged to clade... of strains belonging to subclades A2, B1, and B2 from this... VP1. Strains assigned to subclade A2 carried an arginine and lysine... Number a Cox A10 12 Cox A2 8 Cox A4 21 Cox A5... C-terminus of VP1 of subclade A2 strains, combined with their occurrence... German strains assigned to subclade A2 were identified in seven of... patients. Those strains carried a subclade A2 specific insertion of two amino... authors, 2016. www.eurosurveillance.org Research article Is the recent emergence..., London, United Kingdom 2. Centre for Research on Drugs and Health Behaviour... differences are unknown and further research is required to explore this... A, Hickman M, Sutton A, Stimson GV, Parry JV, et al. HIV prevalence among... MJ, Hope VD, Hickman M, Parry JV, Ncube F, Ramsay ME, et al...: 19546152 22. Connell JA, Parry JV, Mortimer PP, Duncan J. Novel assay... VD, Croxford S, Shute J, Ncube F, Parry JV. Factors associated with recently acquired... Lambeth, Southwark & Lewisham. London: Sigma Research, London School of Hygiene and...



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... of Industrial Engineering and Operations Research. We thank our respective universities...: Input: A sequence of n numbers ha1 ; a2 ; : : : ; an i. Output: A permutation (reordering) ha10... 1: Input: A sequence of n numbers ha1 ; a2 ; : : : ; an i. Output: A permutation (reordering) ha10...: Input: A sequence of n numbers A D ha1 ; a2 ; : : : ; an i and a value . Output: An... a polynomial P .x/ D n X ak x k kD0 D a0 C x.a1 C x.a2 C C x.an 1 C xan / // ; given the coef... master theorem 99 f .n/ f .n/ a f .n=b/ … f .n=b/ a af .n=b/ f .n=b/ a a logb n a … a … a … a … a … a … ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ f .n=b 2 / f .n=b 2 /…f .n=b 2 / a … … a … a2 f .n=b 2 / a … … f .n=b 2 / f .n=b 2 /…f .n=b 2 / f .n=b 2 / f .n=b 2 /…f .n=b 2 / ‚.nlogb a / ‚.1/ ‚.1/ ‚.1/ nlogb a X logb n 1 Total: ‚.nlogb... / … f .n2 / a … f .n2 / a … a … f .n2 / … f .n2 / a … a … ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ ‚.1/ f .n2 / a … … a2 f .n2 / f .n2 / … f .n2 / a … a … … f .n2 / ‚.nlogb...: Input: A sequence of n numbers ha1 ; a2 ; : : : ; an i. Output: A permutation (reordering) ha10... sorted ordering is a3 D 5 Ä a1 D 6 Ä a2 D 8. There are 3Š D 6 possible permutations of... for any nonnegative integer a: ! a : (11.6) a2 D a C 2 2 We have "m 1 # X nj2 E j D0 !!# nj... 371 .A1 .A2 .A3 A4 /// ; .A1 ..A2 A3 /A4 // ; ..A1 A2 /.A3 A4 // ; ..A1 .A2 A3 //A4 / ; ...A1 A2 /A3 /A4.... Suppose we have a set S D fa1 ; a2 ; : : : ; an g of n proposed activities that... a0 RECURSIVE -ACTIVITY-SELECTOR(s, f, 0, 11) m=1 a2 RECURSIVE -ACTIVITY-SELECTOR(s, f, 1, 11) a1... since X w 0 .e/ w 0 .A/ D with jV j e2A X .w0 D w.e// e2A D .jV j 1/w0 X w.e/ e2A D .jV j 1/w0 w.A/ for any... for an undirected graph G D .V; E/ is a jV j jEj matrix M such that M e D 1 if..., we have A0 .1/ D 1 C 1 D 2, A1 .1/ D 2 1 C 1 D 3, and A2 .1/ D 21C1 .1 C 1/ 1 D 7. 574 Chapter 21 Data... Disjoint Sets We also have A.2/ 2 .1/ A2 .A2 .1// A2 .7/ 28 8 1 211 1 2047 A3 .1/ D D D D D D and... that the vertices are numbered 1; 2; : : : ; jV j in some arbitrary manner. Then... representation of a graph G consists of a jV j jV j matrix A D .aij / such that ( 1 if... operations take O.E ˛.V // time. Moreover, since ˛.jV j/ D O.lg V / D O.lg E/, the total running... at most jV j 1 edges, and so k Ä jV j 1. Each of the jV j 1 iterations of... loop of lines 4–8 iterates exactly jV j times. Because Dijkstra’s algorithm always... that there exists a sequence of jV j 1 relaxation steps that produces :d D ı.s; / for... sort h 1 ; acyclic with topological sort h jV j ; jV j 1 ; : : : ; 1 i. 2; :::; jV j i and that Gb is Suppose... each vertex in the order jV j ; jV j 1 ; : : : ; 1 , relaxing edges of Eb that... wi .u; / D 2wi 1 .u; / C 1. Then, prove that 2ıi 1 .s; / Ä ıi .s; / Ä 2ıi 1 .s; / C jV j for all 1 .u; / or 1 2 V. d. Define... a general directed graph G D .V; E/ is then f .jV j ; jEj/ C O.V C E /. 25.3 Johnson’s algorithm for.... The algorithm returns the usual jV j jV j matrix D D dij , where dij D ı.i; j /, or... lg V = lg V /5=4 /. Another line of research demonstrates that we can apply... improve upon running Dijkstra’s algorithm jV j times when jE j D o.E/. Baswana, Hariharan... can become critical at most .jV j 2/=2 D jV j =2 1 times more, for a total of... E, directed from L to R, along with jV j new directed edges: E 0 D f.s; u/ W u 2 Lg [ f.u; / W .u; / 2 Eg... G. A function h W V ! N is a height function3 if h.s/ D jV j, h.t/ D 0, and h.u/ Ä h. / C 1 for every residual edge... initial height function h, given by ( jV j if u D s ; u:h D (26.16) 0 otherwise : Equation..., p is a simple path, and so k < jV j. For i D 0; 1; : : : ; k 1, edge . i ; i C1 / 2 Ef . Because...-relabel algorithms 743 we have h.s/ Ä k < jV j, which contradicts the requirement that... -P USH -R ELABEL on G, we have u:h Ä 2 jV j 1 for all vertices u 2 V . Proof The... any vertex u 2 V fs; tg. Initially, u:h D 0 Ä 2 jV j 1. We shall show that after... relabeling operation, we still have u:h Ä 2 jV j 1. When u is 26.4 Push-relabel... s in Gf . Let p D h 0 ; 1 ; : : : ; k i, where 0 D u, k D s, and k Ä jV j 1 because p is simple. For i D 0; 1; : : : ; k 1, we... these inequalities over path p yields u:h D 0 :h Ä k :h C k Ä s:h C .jV j 1/ D 2 jV j 1. Corollary 26.21 (Bound on... at most 2 jV j 1 per vertex and at most .2 jV j 1/.jV j 2/ < 2 jV j2 overall. Proof Only the jV j 2 vertices in... operations performed is at most .2 jV j 1/.jV j 2/ < 2 jV j2 . Lemma 26.20 also... u and , there are fewer than 2 jV j saturating pushes between u and . Multiplying... nonsaturating pushes is less than 4 jV j2 .jV j C jEj/. P Proof Define... to be less than .2 jV j/.2 jV j2 / C .2 jV j/.2 jV j jEj/ D 4 jV j2 .jV j C jEj/. Since ˆ 0, the... nonsaturating pushes, is less than 4 jV j2 .jV j C jEj/. Having bounded the... the properties that u:h < jV j implies u:h Ä ıf .u; t/ and that u:h jV j implies u:h jV j Ä ıf .u; s/. 26.4-9 ? As in... the property that u:h < jV j implies u:h D ıf .u; t/ and that u:h jV j implies u:h jV j D ıf .u; s/. The total time...



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... Leader, Animal Health USDA, Agriculture Research Service Beltsville, MD Mark L. Hemphill... Biosafety Level Criteria for Vivarium Research Facilities................................................................ 60 Animal Biosafety Level..................................................................................................... 392 Appendix J—NIH Oversight of Research Involving Recombinant Biosafety Issues.......................................................... 394... maintaining safe conditions in biological research. Evolution of National Biosafety Guidelines... Cancer Institute safety standards for research involving oncogenic viruses. Bethesda: The... Group Classification NIH Guidelines for Research involving Recombinant DNA Molecules 20022... appropriate practices and procedures for research involving constructing and handling both... DNA research, including institutions, investigators, and the NIH. Recombinant DNA research subject... Biotechnology Activities. NIH guidelines for research involving recombinant DNA molecules. Bethesda..., Pollack R, editors. Biohazards in biological research. Proceedings of a conference held at... applicable to clinical, diagnostic, teaching, research, or production facilities in which... applicable to clinical, diagnostic, teaching, research, or production facilities where work... animal research. The following publication by the Institute for Laboratory Animal Research... Biosafety Level Criteria for Vivarium Research Facilities: ABSL-1 61 2. A safety manual... hazards (physical, naturally occurring, or research pathogens, allergens, etc.) and are... Biosafety Level Criteria for Vivarium Research Facilities: ABSL-2 71 C. Safety Equipment... Biosafety Level Criteria for Vivarium Research Facilities: ABSL-3 77 8. Eating, drinking... Biosafety Level Criteria for Vivarium Research Facilities: ABSL-4 87 7. Decontaminate work... 1, 2, 3 (1976). 3. National Research Council; Institute for Laboratory Animal Research. Occupational health and safety in the care and use of research animals. Washington, DC: National Academy Press; 1997. 4. National Research Council; Institute for Laboratory Animal Research. Occupational health and... Biosafety Level Criteria for Vivarium Research Facilities 103 ■■ Agents associated with... control over and account for research materials, protect relevant sensitive information... research-related information. This is accomplished by limiting access to facilities, research... responsibility; control and accountability for research materials including microorganisms and culture... professional responsibility for management of research materials by adherence to appropriate... environments of today’s biomedical and research laboratories. Biosecurity program managers should... Medical support services for biomedical research facilities should be evaluated annually...) and appropriate Institutional Human Subjects Research Protection Committees.17,18 Recommendation... Program, United States Army Medical Research Institute of Infectious Diseases (USAMRIID... Research Council (US), Committee on Occupational Safety and Health in Research Animal... research animals. Washington, DC: The National Academies Press; 1997. 10. National Research.... Q fever control measures: Recommendations for research facilities using sheep. Infect Control... introduced into a laboratory for diagnostic/research purposes.56 Occupationally-acquired, nosocomial... procedures are recommended for diagnostic, research and production activities utilizing contemporary...) Manipulating HPAI viruses in biomedical research laboratories requires similar caution because..., or aerosol inhalation. Diagnostic and research activities involving clinical material, infectious... Simian Hemorrhagic Fever SHFV Arterivirus 2 A2 Simian Hemorrhagic Fever No Sindbis..., MD. Aberdeen, Maryland: U.S. Army Chemical Research, Development and Engineering Center; 1989... Cancer Institute Safety Standards for Research Involving Chemical Carcinogens. Bethesda: The... symposium on design of biomedical research facilities. Monograph series. Volume 4; l979... Department of Agriculture (USDA), Agricultural Research Services (ARS). ARS construction project.... The inanimate environment. In: Bennett JV, Brachmann PS, editors. Hospital infections... research involving high consequence livestock pathogens in animal species or other research where the room provides the primary containment. To support such research... requirements should be addressed in a research facility’s planning, design, and construction... Sciences, Mathematics, and Applications; National Research Council. Prudent practices in the... biosafety practices and procedures for research involving the construction and handling... entities associated with recombinant DNA research, including institutions, investigators, biological safety... Immunoglobulin Institute for Laboratory Animal Research Investigational New Drug Integrated Pest... Spongiform Encephalopathy Ultraviolet U.S. Army Medical Research Institute of Infectious Diseases U.S. Department...



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.../123456789/12547 Information about this research object was correct at the... Andrew Batty, confirm that the research included within this thesis is... the opportunity to pursue my research interests in haemophilia. Dan’s support... B domain deleted Factor VIII RCSB Research collaboratory for structural bioinformatics rFVIIa... RNA-Seq RNA sequencing RODIN Research Of determinants of Inhibitor development... Web Based Questionnaires in Healthcare Research 5.5.6 Aging Population in the United... spanning the end of the A2/a2 domain through the truncated B domain... the junctions of the a1-A2, a2-B and a3-A3 domains respectively... modelled to residues within the A2/a2 (484-509, 558-565 and... though spontaneous dissociation of the A2 domain 46;47. Proteinase mediated.... The second of these, the Research Of Determinants of INhibitor development... are of interest for further research, as differences between endogenous and... with congenital haemophilia A within the A2 and C2 domains (68%) and... been described in clinical and research settings, including enzyme linked immunosorbent... of reports of commercial and research laboratory ELISAs for FVIII antibody... have compared the use of a research laboratory based FVIII ELISA with... data in severe haemophilia A. Further research is required to define optimal... Royal London Hospital and Research Approvals Office (Joint Research Management Office). The... (INSERM) 313 and by our research group 314 have attempted to... numbers of patients 317 . Further research is ongoing in this area... Web Based Questionnaires in Healthcare Research With the increased routine use... and the impact of recent research on their clinical practice 332... policy, identify areas of required research and inform potential future study... are conflicting data from previous research as to factors that may... detection of FVIII antibodies in research settings (discussed in Chapter 1), which... and in-house ELISAs in research 118 settings, this approach is... assays 286 and in validated research-laboratory ELISAs 258;367;368... part 2 were discussed with the research approvals department at Queen Mary... Haemophilia A There has been increased research interest in the usage of... cohorts. There has been substantial research interest over the last three...: C5, Prof. Z.M. Ruggeri (The Scripps Research Institute, La Jolla, CA, USA... the following domains: A1=5; a1=0; A2=4; a2=1; B=4; a3=0; A3=5; C1=2; C2=2 (1 C2... 98.2% (1-2290): A1/a1 (100%), A2/a2 (100%), B (100%), a3/A3 (100...: 2R7E) 7 was obtained from the Research Collaboratory for Structural Bioinformatics (RCSB...) demonstrates a shared epitope in the a2 domain between positions 716-745... the following regions 491510 (A2), 736-760 (a2), 1701-1730 (A3) and... found Domain epitopes A1, a1, A2, a2, B, a3 Low resolution sequence epitopes... 3 193 i22 inv A1, a1, A2, a2, B, a3 96-125; 316-365...-1665 6 26 i22 inv A1, A2, a2, B, A3 11-35; 231-255... 7 96 i22 inv A1, a1, A2, a2, B 331-355; 701-725; 1151... 80 Not available A1, a1, A2, a2, A3 191-205; 231-255... 14 4 Nonsense (Ex10) A1, a1, A2, a2#, A3 191-205; 231-255... F LOOP 381-400 (386-395) A2 3 Functional regions Calcium K107, E110... interaction site M337-R372 A1-A2 interaction site FVIIIa inactivation (APC... Y346 Disulphide bond C248-C329 A2-A1/A3C1C2 interaction Ser373-Trp393...-465 (451-465) A2 2 - H SHARED 701-730 (706-725) A2/a2 6 I J K L M N O P LIN LIN... (12/13), a1 (11/13), A2 (7/13), a2 (6/13), B (10/13), a3... observed. 179 a1 A2 =2 E: 316-365 A2 F: 381-400 a2 D: 231-255 a1... a domain level. Binding for the A2 domain mAb R8B12, although falling... differences in coverage of the A2 domain between my experiments (100... the C-terminal region of the A2/a2 domain. 182 8.5.2 Factor VIII Immunogenicity... patients contain epitopes towards the A2 domain. A recently published study investigating... the immune response to the A2 domain has shown overlapping epitopes... first epitopes characterised in the A2 domain as being immunodominant by... terminal acidic region of the A2 domain (a2) between positions 712736 391... proportionate review by the Joint Research Management Office (Barts Health NHS... has mainly limited usage to research settings and does not provide..., Rydkin I, Fay PJ. Factor VIIIa A2 subunit shows a high affinity interaction..., Duncan BM, Tunbridge LJ, Lloyd JV. Familial discrepancy between the onestage... D, Mattingly M, Prescott R. A recombinant factor VIII A2 domain polypeptide quantitatively neutralizes human... rates from physicians in oncology research: a structured literature review and data... and implications for health care, research, and medical education: a cross-sectional... in the US Hemophilia Inhibitor Research Study. J Thromb Haemost 2013; 11... from B-cell protein antigens. Immunome Research 2011; 7(3):1-11. (404) Sivalingam GN...; 51(3-4):304-309. (405) Kringelum JV, Nielsen M, Padkjaer SB, Lund O. Structural... stabilization of the factor VIII A2 domain enhances efficacy in hemophilia... and specificity'). Introduction 2 State the research questions or study aims, such... whole blood (mRNA) samples for research purposes to investigate the mechanisms...